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. 1997 Oct;22(4):235-41.
doi: 10.1016/s0143-4160(97)90062-2.

Ionophoretic properties of ferutinin

M V Zamaraeva  1 , A I Hagelgans, A Y Abramov, V I Ternovsky, P G Merzlyak, B A Tashmukhamedov, A I Saidkhodzjaev
Affiliations

Ionophoretic properties of ferutinin

M V Zamaraeva et al. Cell Calcium. 1997 Oct.

Abstract

The influence of the natural terpenoid ferutinin (4-oxy-6-(4-oxybenzoyloxy) dauc-8,9-en), isolated from the plant Ferula tenuisecta, on ion permeability of biological and artificial membranes was investigated. It was shown that ferutinin, in the concentration range 1-50 microM, increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes (BLM) for Ca2+. Ferutinin establishes a transmembrane potential in BLM equal to the Nernst's potential. The permeability ratio for Na+/Ca2+ is 0.41. The dependence of BLM conductivity on ferutinin concentration is linear. The stoichiometry of the ferutinin:Ca2+ complex is 2, assuming the formation of a structure with participation of two terpenoid molecules and one Ca2+ ion.

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