Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Jan;6(1):23-7.
doi: 10.1016/S0966-842X(97)01145-1.

The role of CpG dinucleotides in DNA vaccines

A M Krieg  1 , A K Yi, J Schorr, H L Davis
Affiliations
Review

The role of CpG dinucleotides in DNA vaccines

A M Krieg et al. Trends Microbiol. 1998 Jan.

Abstract

DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

PubMed Disclaimer

Publication types

LinkOut - more resources