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. 1976 Aug 20;193(4254):678-80.
doi: 10.1126/science.948742.

Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro

K P Chang, D M Dwyer

Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro

K P Chang et al. Science. .

Abstract

Leishmania donovani, the etiological agent of human visceral leishmaniasis, was grown in hamster peritoneal macrophages in vitro. By electron microscopy, using a lysosomal marker, these parasitic protozoa were seen to multiply within host cell phagolysosomes. The survival mechanism of this intracellular parasite is based apparently upon resistance to macrophage lysosomal enzymic digestion.

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