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Case Reports
. 1998 Feb;100(2):348-50.
doi: 10.1046/j.1365-2141.1998.00572.x.

Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

T Miyamoto  1 , H Gondo, Y Miyoshi, H Shigematsu, T Minematsu, K Takenaka, K Tanimoto, T Horiuchi, Y Asano, S Inaba, Y Minamishima, Y Niho
Affiliations
Case Reports

Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

T Miyamoto et al. Br J Haematol. 1998 Feb.

Abstract

A patient with non-Hodgkin's lymphoma who received a CD34-selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus-associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4+ lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus-associated HC. Immunosuppression and resultant viral infections may affect patients receiving CD34-selected autologous transplantation.

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