Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Feb;21(3):217-20.
doi: 10.1038/sj.bmt.1701076.

Electroencephalogram abnormality and high-dose busulfan in conditioning regimens for stem cell transplantation

R Kobayashi  1 , N Watanabe, A Iguchi, Y Cho, M Yoshida, H Arioka, H Naito, T Shikano, Y Ishikawa
Affiliations

Electroencephalogram abnormality and high-dose busulfan in conditioning regimens for stem cell transplantation

R Kobayashi et al. Bone Marrow Transplant. 1998 Feb.

Abstract

High-dose busulfan (BU) is widely used in combined chemotherapy before allogeneic or autologous bone marrow transplantation. Convulsions are reported as a side-effect of high-dose BU. We recorded electroencephalograms (EEGs) before and on the third day of BU administration in 22 patients. Abnormal EEGs were observed on the third day in 13 cases (59%). These patients were older (P < 0.05) and had had larger doses of BU (P < 0.025) than the nine patients with normal EEGs. Convulsions occurred in two of the 22 patients, one of whom was receiving prophylaxis with phenytoin. Gamma aminobutyric acid (GABA), a natural mediator of defense against epileptic activity, concentrations in cerebrospinal fluid measured before and after administration of BU showed no definite changes.

PubMed Disclaimer

LinkOut - more resources