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. 1976 Jun 1;155(3):717-9.
doi: 10.1042/bj1550717.

Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide

D B Coult

Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide

D B Coult. Biochem J. .

Abstract

Cholinesterases are inhibited by 2-fluoro-1,3,2-dioxaphosphorinane 2-oxide by a mechanism that involves a slow association step followed by a very slow phosphorylation step. No phosphorylation step was observed for the interaction between acetylcholinesterase and 2-S-[2'-(NN-diethylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-oxide.

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