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. 1976 Jun 15;156(3):515-20.
doi: 10.1042/bj1560515.

Glucagon-like and insulin-like hormones of the insect neurosecretory system

H S Tager, J Markese, K J Kramer, R D Speirs, C N Childs

Glucagon-like and insulin-like hormones of the insect neurosecretory system

H S Tager et al. Biochem J. .

Abstract

Aqueous extracts of corpus cardiacum-corpus allatum complexes of the adult tobacco hornworm Manduca sexta produced both glycogenolysis and hypoglycaemia when injected into the larval form of the same species. Application of specific radioimmuno assays to similar extracts showed also that these gland complexes contain both glucagon-like and insulin-like peptides. Further, the partially purified immunoreactive peptides had the expected biological activities. The former decreased the glycogen content of the fatbody and the latter the circulating trehalose levels in recipient animals. These results suggest the existence of hormones in these invertebrates having both biological and structural similarities to vertebrate insulin and glucagon.

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References

    1. Comp Biochem Physiol A Comp Physiol. 1975 Jan 1;50(1A):165-7 - PubMed
    1. Comp Biochem Physiol A Comp Physiol. 1975 Jun 1;51(2):483-5 - PubMed
    1. Nature. 1975 Mar 20;254(5497):259-61 - PubMed
    1. Nature. 1975 Apr 24;254(5502):707-8 - PubMed
    1. Gen Comp Endocrinol. 1972 Feb;18(1):83-8 - PubMed

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