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Multicenter Study
. 1998 Feb;79(2):359-61.

The histidin-rich glycoprotein Pro186/Ser polymorphism is not related to myocardial infarction in the ECTIM study

S M Herrmann  1 , O Poirier, V Nicaud, J B Ruidavets, A Evans, D Arveiler, G Luc, L Bara, F Cambien
Affiliations
  • PMID: 9493591
Multicenter Study

The histidin-rich glycoprotein Pro186/Ser polymorphism is not related to myocardial infarction in the ECTIM study

S M Herrmann et al. Thromb Haemost. 1998 Feb.

Abstract

The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.

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