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Clinical Trial
. 1998 Feb;15(2):76-81.

Dextropropoxyphene versus morphine in opioid-naive cancer patients with pain

Affiliations
  • PMID: 9494305
Free article
Clinical Trial

Dextropropoxyphene versus morphine in opioid-naive cancer patients with pain

S Mercadante et al. J Pain Symptom Manage. 1998 Feb.
Free article

Abstract

The role of opioids for moderate pain (so-called "weak" opioids) in the second step of the World Health Organization's analgesic ladder has been investigated in a prospective randomized study. Sixteen patients were administered dextropropoxyphene (DPP) in a dosage ranging from 120 mg to 240 mg daily (group 1), and 16 patients were administered the lowest doses (20 mg daily) of commercially available controlled-release morphine (group 2). Equianalgesic doses of oral morphine, pain relief, and symptoms during the first 10 days of therapy and during the last 4 weeks before death were assessed. Three of 16 patients maintained DPP until death, whereas three patients in group 2 were switched to DPP due to the occurrence of intolerable side effects. Intensity and frequency of nausea and vomiting, drowsiness, and dry mouth were higher in group 2 than in group 1 during the initial treatment. These results stress the role of "weak" opioids during the induction of opioid therapy in opioid-naive cancer patients.

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