Comparative Study
The effect of quipazine and LSD on monoamines in the rat striatum
- PMID: 94944
Item in Clipboard
Comparative Study
The effect of quipazine and LSD on monoamines in the rat striatum
Pol J Pharmacol Pharm.
1979 Sep-Oct.
Abstract
Rats given quipazine (5 mg/kg) or LSD (0.05 mg/kg), were decapitated at the time of maximum of behavioral effect of drugs (head twitches), resp. 30 and 15 min, or when the behavioral effects disappeared (resp. 60 and 30 min), and concentrations of dopamine (DA), noradrenaline (NA), serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were assayed in the striatum. Quipazine significantly elevated the DA level at both periods tested. LSD at the peak of its action depressed the level of 5-HIAA, and in the next period produced a significant depression of striatal levels of NA, 5HT and 5-HIAA.
Similar articles
-
Head twitches produced by serotonergic drugs and opiates after lesion of the mesostriatal serotonergic system of the rat.Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):413-23. Pol J Pharmacol Pharm. 1979. PMID: 316525
-
[Quipazine antagonizing baclofen activity. Influence of baclofen and gamma-hydroxybutyric acid on serotonin metabolism in rat brain (author's transl)].Arzneimittelforschung. 1978;28(9):1507-8. Arzneimittelforschung. 1978. PMID: 582544 German.
-
Effects of meclofenoxate on the level and turnover of biogenic monoamines in the rat brain.Arzneimittelforschung. 1985;35(12):1778-81. Arzneimittelforschung. 1985. PMID: 2420335
-
The serotonergic system in the brain and its possible functional connections with other aminergic systems.Life Sci. 1975 Oct 15;17(8):1201-9. doi: 10.1016/0024-3205(75)90128-9. Life Sci. 1975. PMID: 574 Review. No abstract available.
-
Special chemistry of the basal ganglia I. Monoamines.Pharmacol Ther B. 1975;1(1):49-61. doi: 10.1016/0306-039x(75)90015-x. Pharmacol Ther B. 1975. PMID: 817320 Review. No abstract available.
Cited by
-
The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced locomotor activity.J Neural Transm. 1982;54(3-4):145-51. doi: 10.1007/BF01254924. J Neural Transm. 1982. PMID: 7130970 No abstract available.
-
The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor activity.J Neural Transm. 1983;57(1-2):27-37. doi: 10.1007/BF01250045. J Neural Transm. 1983. PMID: 6619829
-
Methysergide blocks the sleep suppressant action of quipazine in rats.Psychopharmacology (Berl). 1982;76(3):255-9. doi: 10.1007/BF00432556. Psychopharmacology (Berl). 1982. PMID: 6808546