Clinical Trial
doi: 10.1016/S0006-3223(97)00010-3.
Tryptophan depletion in recently manic patients treated with lithium
Affiliations
- PMID: 9494705
- DOI: 10.1016/S0006-3223(97)00010-3
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Clinical Trial
Tryptophan depletion in recently manic patients treated with lithium
Biol Psychiatry.
.
Abstract
Background: Serotonin has been repeatedly implicated in the mechanism of action of lithium against acute mania. Its role, however, has never been directly confirmed.
Methods: We studied recently manic patients successfully treated with lithium using a tryptophan depletion methodology.
Results: Patients remained euthymic despite a confirmed decrease in serum tryptophan levels.
Conclusions: These data do not suggest that serotonin plays a critical role in the acute antimanic effect of lithium.
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