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. 1997 Oct;73(864):640-1.
doi: 10.1136/pgmj.73.864.640.

Diazoxide treatment for insulinoma: a national UK survey

G V Gill  1 , O Rauf, I A MacFarlane
Affiliations

Diazoxide treatment for insulinoma: a national UK survey

G V Gill et al. Postgrad Med J. 1997 Oct.

Abstract

A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment. Mean age (+/- SD) was 67 +/- 18 years, and 74% were female. Duration of treatment was 7 +/- 6 years (range 1-22). Most (55%) patients were treated with diazoxide because of tumour non-localisation (including failed previous surgery). Metastatic disease (20%) and poor surgical risk (10%) were other indications. Side-effects (notably fluid retention and hirsutism) were common (47%) but not troublesome. Treatment was highly effective--59% were symptom free and 38% had only occasional symptoms. Only one patient had frequent hypoglycaemia despite treatment. We conclude that diazoxide is effective in the management of insulinoma. Side-effects are common but not problematic. Treatment should be considered for all patients not cured by surgery, or unsuitable for surgical treatment.

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References

    1. Ann N Y Acad Sci. 1968 Apr 11;150(2):303-8 - PubMed
    1. Acta Diabetol Lat. 1974 Jan-Feb;11(1):71-7 - PubMed
    1. Diabete Metab. 1994 Mar-Apr;20(2):157-62 - PubMed
    1. World J Surg. 1986 Aug;10(4):586-92 - PubMed
    1. Annu Rev Med. 1979;30:313-29 - PubMed