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. 1998 Feb 13;124(1):53-7.
doi: 10.1016/s0304-3835(97)00449-7.

In situ detection of Epstein-Barr virus in breast cancer

J S Chu  1 , C C Chen, K J Chang
Affiliations

In situ detection of Epstein-Barr virus in breast cancer

J S Chu et al. Cancer Lett. .

Abstract

Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

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