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. 1997 Dec;47(12):889-91.
doi: 10.1111/j.1440-1827.1997.tb03723.x.

Why is cyclooxygenase-2 expressed in neuroendocrine cells of the human alimentary tract?

T Nakajima  1 , K Hamanaka, T Fukuda, T Oyama, K Kashiwabara, T Sano
Affiliations

Why is cyclooxygenase-2 expressed in neuroendocrine cells of the human alimentary tract?

T Nakajima et al. Pathol Int. 1997 Dec.

Abstract

During immunohistochemical studies of cyclooxygenase-2 (COX-2) on human colon cancers, many strong COX-2-immunoreactive cells scattered in the bottom of the crypt of normal colon mucosa were unexpectedly noticed. COX-2-immunoreactive cells were morphologically very similar to neuroendocrine cells and were confirmed immunohistochemically to be positive for chromogranin A or serotonin. Moreover, COX-2-immunoreactive neuroendocrine cells were observed not only in the large intestine, but also in the stomach, duodenum and small intestine. The role of COX-2 expression in neuroendocrine cells of the human alimentary tract was speculated.

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