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Review
. 1997 Nov-Dec;43(6):471-81.

[Oxidative modification of monoamine oxidase]

[Article in Russian]
A E Medvedev  1 , K F Tipton
Affiliations
  • PMID: 9503564
Review

[Oxidative modification of monoamine oxidase]

[Article in Russian]
A E Medvedev et al. Vopr Med Khim. 1997 Nov-Dec.

Abstract

Oxidative modification of monoamine oxidases (MAO) accompanied by alteration of their substrate specificity and sensitivity to specific inhibitors was discovered by Professor V.Z. Gorkin more than 30 years ago. The mechanism of this phenomenon includes oxidation of SH groups of the enzyme. Oxidative modification of MAO is also accompanied by increased sensitivity to limited proreolysis. Modification of MAO was found in many pathological states, however, elucidation of biological role of this phenomenon requires further investigations.

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