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. 1976 May;257(2):495-502.
doi: 10.1113/jphysiol.1976.sp011380.

Subcellular localization of the heparin-neutralizing factor in blood platelets

M Da Prada, M Jakábová, E F Lüscher, A Pletscher, J G Richards

Subcellular localization of the heparin-neutralizing factor in blood platelets

M Da Prada et al. J Physiol. 1976 May.

Abstract

1. The distribution of the heparin-neutralizing factor (platelet factor 4, PF4) in subcellular organelles of blood platelets of rabbits and man was investigated. 2. In both species the organelles storing 5-hydroxytryptamine (5-HT storage organelles) contained only trivial amounts of PF4. 3. In contrast, the content of PF4 was highest in the subcellular fractions rich in alpha-granules. 4. In conclusion, PF4 is probably localized in the alpha-granules and therefore the platelets contain at least two types of organelles (5-HT organelles and alpha-granules) capable of releasing their contents in response to the same stimuli, such as exposure to collagen, thrombin, etc.

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