Second and early third trimester pregnancy termination by extra-amniotic balloon and intracervical PGE2

Abstract

Objective: The aim of the study was to investigate the efficacy and safety of an alternative modality using extra-amniotic balloon and intracervical prostaglandin (PG) E2 for termination of second and early third trimester pregnancies.

Method: Thirty-three pregnant women scheduled for legal termination of pregnancy at 15-32 weeks' gestation were included in the study. Each case received extra-amniotic balloon containing 500-800 ml normal saline and two PGE2 tablets inserted into the cervical canal.

Results: All 33 patients achieved a successful termination. The mean induction-to-abortion interval was 12.85 h. There was no significant difference in induction-to-abortion interval between second trimester group and third trimester group. However, the mean duration of balloon distention was longer in the second trimester group. There were no severe complications.

Conclusion: The combined use of extra-amniotic balloon and intracervical PGE2 tablets is effective, safe and convenient for termination of second and early third trimester pregnancy.