Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Mar;29(3):613-7.
doi: 10.1161/01.str.29.3.613.

Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression

B S Greenwald  1 , E Kramer-Ginsberg, K R Krishnan, M Ashtari, C Auerbach, M Patel
Affiliations

Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression

B S Greenwald et al. Stroke. 1998 Mar.

Abstract

Background and purpose: Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited.

Methods: T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions.

Results: Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment.

Conclusions: Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.

PubMed Disclaimer

Publication types