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. 1998 Feb;132(2):352-4.
doi: 10.1016/s0022-3476(98)70460-3.

Omeprazole in infants with cimetidine-resistant peptic esophagitis

P Alliët  1 , M Raes, E Bruneel, P Gillis
Affiliations

Omeprazole in infants with cimetidine-resistant peptic esophagitis

P Alliët et al. J Pediatr. 1998 Feb.

Abstract

Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.

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