Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Apr 1;26(7):1551-9.
doi: 10.1093/nar/26.7.1551.

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

W S Dynan  1 , S Yoo
Affiliations
Review

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

W S Dynan et al. Nucleic Acids Res. .

Abstract

The Ku protein-DNA-dependent protein kinase system is one of the major pathways by which cells of higher eukaryotes respond to double-strand DNA breaks. The components of the system are evolutionarily conserved and homologs are known from a number of organisms. The Ku protein component binds directly to DNA ends and may help align them for ligation. Binding of Ku protein to DNA also nucleates formation of an active enzyme complex containing the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). The interaction between Ku protein, DNA-PKcs and nucleic acids has been extensively investigated. This review summarizes the results of these biochemical investigations and relates them to recent molecular genetic studies that reveal highly characteristic repair and recombination defects in mutant cells lacking Ku protein or DNA-PKcs.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1992 Jul 25;20(14):3784 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6958-62 - PubMed
    1. Cell. 1992 Nov 27;71(5):833-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11920-4 - PubMed
    1. Cell. 1993 Jan 15;72(1):131-42 - PubMed

Publication types

MeSH terms