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Clinical Trial
. 1998 Feb;15(2):62-4.
doi: 10.1007/BF02766826.

Assisted hatching does not enhance IVF success in good-prognosis patients

B S Hurst  1 , K E Tucker, C A Awoniyi, W D Schlaff
Affiliations
Clinical Trial

Assisted hatching does not enhance IVF success in good-prognosis patients

B S Hurst et al. J Assist Reprod Genet. 1998 Feb.

Abstract

Purpose: The role of assisted hatching in good-prognosis IVF patients was evaluated in a prospective, randomized, controlled pilot study, which was followed by a retrospective observational series.

Methods: After assisted hatching was proved successful in a mouse embryo study, 20 good-prognosis IVF patients were randomly assigned to either assisted hatching (13) or no assisted hatching (7; the controls). Following this series, 27 good-prognosis IVF patients were retrospectively evaluated to determine the outcome with assisted hatching.

Results: In the prospective study, clinical pregnancies resulted from 3 (23%) of 13 patients in the hatching group, compared to 3 (43%) of 7 in the control group. Implantation rates were similar: 9.6% in the hatching group and 10.7% in the controls. In the retrospective series, the 11.1% implantation rate with assisted hatching was significantly less than the 42.9% implantation rate seen with traditional IVF.

Conclusions: Implantation and pregnancy rates are high in young women undergoing traditional IVF. Assisted hatching is not beneficial in these patients.

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