Effects of controllable and uncontrollable stresses on the receptor binding of dexamethasone in the hypophysis and hippocampus of rats with different behavior strategies

Abstract

The effects of controllable and uncontrollable stress on the receptor binding of dexamethasone in the hypophysis and hippocampus were studied in KHA and KLA rats, lines selected for the ability to development of active escape. Presentation of the controllable stimulus led to a significant reduction in receptor binding of dexamethasone in the hippocampus with significant changes in the plasma corticosterone concentration and receptor binding in the hypophysis. KLA rats were sensitive both to the controllable and the uncontrollable stresses, with increases in plasma corticosterone and receptor binding of dexamethasone in the hypophysis. It is concluded that receptor binding of dexamethasone in the hippocampus and hypophysis depend not only on the behavioral strategy of the animal, but also on the possibility of controlling the situation.