Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Feb;27(4):226-44.
doi: 10.1016/s0049-0172(98)80003-6.

Role of the new azoles in the treatment of fungal osteoarticular infections

A Pérez-Gómez  1 , A Prieto, M Torresano, E Díez, J Mulero, I Labiano, J L Andreu
Affiliations
Review

Role of the new azoles in the treatment of fungal osteoarticular infections

A Pérez-Gómez et al. Semin Arthritis Rheum. 1998 Feb.

Abstract

Objectives: To analyze the usefulness of the new azoles for the treatment of fungal osteoarticular infections, and to report three cases of fungal knee arthritis treated with fluconazole in our unit.

Methods: The medical literature was reviewed for all cases of osteoarticular infection caused by fungi and treated with fluconazole or itraconazole registered in the MedLine Silver Platter database from 1972 to 1997.

Results: The total number of patients included in this review was 56; 19 were treated with fluconazole and 37 with itraconazole. The most frequent causative agents implicated were fungi of the genuses Candida and Aspergillus. There were eight therapeutic failures, and there were no statistically different findings among the patients in terms of their health status. Adverse effects were unusual.

Conclusions: Controlled studies are necessary to establish the true role of the new azole drugs in the treatment of fungal osteoarticular infections, but they seem to be a promising therapeutic option.

PubMed Disclaimer

LinkOut - more resources