Apomorphine self-injection is not affected by alpha-methylparatyrosine treatment: support for dopaminergic reward

Abstract

Pretreatment with AMPT at doses which markedly altered the self-injection or amphetamine did not affect the self-injection of apomorphine. These data support the idea that the self-injection of apomorphine is produced via the direct activation of dopamine receptors rather than by the release of either norepinephrine or dopamine.