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. 1976 Apr 15;46(3):235-43.
doi: 10.1007/BF00421108.

Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs

O F Bueno, E A Carlini, E Finkelfarb, J S Suzuki

Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs

O F Bueno et al. Psychopharmacologia. .

Abstract

Three groups of rats (A, B, C) were trained in a T-maze discriminate between drug-and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: delta 9-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg(Group C). After discrimination acquisition several drugs were tested for generalization in each group. Group A was tested with delta 8-THC, CBD, CBN, ethanol, pentobarbital,chlorpromazine, amphetamine, and apomorphine; only delta8-THC and CBN induced delta9-THC-like responses. Group B was tested with delta 9-THC, delta 8-THC, CBD, CBN, pentobarbital, and amphetamine; pentobarbital induced ethanol-like response. Group C was tested with delta 9-THC, apomorphine, and ethanol; delta 9-THC and apomorphine elicited amphetamine-like responses.

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References

    1. Psychopharmacologia. 1975;41(3):277-84 - PubMed
    1. Psychopharmacologia. 1974;40(1):1-16 - PubMed
    1. Pharmacology. 1975;13(6):502-12 - PubMed
    1. Psychopharmacologia. 1965 Mar 15;7(3):175-81 - PubMed
    1. Psychopharmacologia. 1973 Oct 23;33(1):53-70 - PubMed