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. 1998 Mar 15;58(6):1140-3.

A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix

J Y Lee  1 , S M Dong, H S Kim, S Y Kim, E Y Na, M S Shin, S H Lee, W S Park, K M Kim, Y S Lee, J J Jang, N J Yoo
Affiliations
  • PMID: 9515797

A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix

J Y Lee et al. Cancer Res. .

Abstract

Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.

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