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Comparative Study
. 1998 Mar;42(3):721-4.
doi: 10.1128/AAC.42.3.721.

Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium

M J Rybak  1 , D M Cappelletty, T Moldovan, J R Aeschlimann, G W Kaatz
Affiliations
Comparative Study

Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium

M J Rybak et al. Antimicrob Agents Chemother. 1998 Mar.

Abstract

The activities of the oxazolidinone antibacterial agents eperezolid (PNU-100592) and linezolid (PNU-100766) were compared with that of vancomycin against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (n = 200), coagulase-negative staphylococci (n = 100), and vancomycin-susceptible and -resistant Enterococcus faecalis and Enterococcus faecium (n = 50). Eperezolid and linezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci (MIC at which 90% of the isolates are inhibited [MIC90] range, 1 to 4 microg/ml) or vancomycin susceptibility for enterococci (MIC90 range, 1 to 4 microg/ml). In time-kill studies, eperezolid and linezolid were bacteriostatic in action. A postantibiotic effect of 0.8+/-0.5 h was demonstrated for both eperezolid and linezolid against S. aureus, S. epidermidis, E. faecalis, and E. faecium.

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Figures

FIG. 1
FIG. 1
Time-kill experiments performed in duplicate. Results are means ± standard deviations. (A and B) Methicillin-resistant S. aureus (R323) and methicillin-susceptible S. epidermidis (R264), respectively. (C and D) Vancomycin (Vanco)-resistant E. faecalis (R581) and E. faecium (R20), respectively.
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