Review
doi: 10.1016/s0959-440x(98)80009-2.
Origin DNA-binding proteins
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- PMID: 9519296
- DOI: 10.1016/s0959-440x(98)80009-2
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Review
Origin DNA-binding proteins
Curr Opin Struct Biol.
1998 Feb.
Abstract
The first step in DNA replication involves the recognition of origin DNA sequences by origin-binding proteins. The three-dimensional structures of three different origin DNA-binding proteins have recently been solved. These proteins form a structural class distinct from other DNA-binding proteins. One of the origin-binding proteins, Epstein-Barr virus nuclear antigen 1, most likely has two modes of DNA binding; the sequential use of these modes may be important for the initiation of DNA replication.
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