Heritable variation in food preferences and their contribution to obesity
- PMID: 9519563
- PMCID: PMC3647229
- DOI: 10.1023/a:1025692031673
Heritable variation in food preferences and their contribution to obesity
Abstract
What an animal chooses to eat can either induce or retard the development of obesity; this review summarizes what is known about the genetic determinants of nutrient selection and its impact on obesity in humans and rodents. The selection of macronutrients in the diet appears to be, in part, heritable. Genes that mediate the consumption of sweet-tasting carbohydrate sources have been mapped and are being isolated and characterized. Excessive dietary fat intake is strongly tied to obesity, and several studies suggest that a preference for fat and the resulting obesity are partially genetically determined. Identifying genes involved in the excess consumption of dietary fat will be an important key to our understanding of the genetic disposition toward common dietary obesity.
References
-
- Allison DB. Methodological issues in obesity research: Examples from biometrical genetics. In: Vanltallie TB, Simopoulos AP, editors. Obesity. New Directions in Assessment and Management. Charles Press; Philadelphia: 1994. pp. 122–132.
-
- Anliker JA, Bartoshuk L, Ferris AM, Hooks LD. Children’s food preferences and generic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) Am J Clin Nutr. 1991;54:316–320. - PubMed
-
- Austin MA, King MC, Bawol RD, Hulley SB, Friedman GD. Risk factors for coronary heart disease in adult female twins. Genetic heritability and shared environmental influences. Am J Epidemiol. 1987;125:308–318. - PubMed
-
- Bachmanov AA, Reed DR, Ninomiya Y, Inoue M, Tordoff MG, Price RA, Beachamp GK. Genetics of sucrose intake in the mouse. Chem Senses. 1996;21:575.
-
- Bacon AW, Miles JS, Schiffman SS. Effect of race on perception of fat alone and in combination with sugar. Physiol Behav. 1994;55:603–606. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases