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. 1979 Dec 6;282(5739):582-6.
doi: 10.1038/282582a0.

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

B R Williams, R R Golgher, R E Brown, C S Gilbert, I M Kerr

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

B R Williams et al. Nature. .

Abstract

Until now the interferon-mediated 2'-5' adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

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