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Review
. 1998 Feb;10(1):59-66.
doi: 10.1016/s0952-7915(98)80033-2.

The pathogenetic role of HLA-B27 in chronic arthritis

J A López de Castro  1
Affiliations
Review

The pathogenetic role of HLA-B27 in chronic arthritis

J A López de Castro. Curr Opin Immunol. 1998 Feb.

Abstract

Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.

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