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. 1979 Oct;1(2):131-9.
doi: 10.1016/0165-1781(79)90053-2.

Aggression in humans correlates with cerebrospinal fluid amine metabolites

G L Brown, F K Goodwin, J C Ballenger, P F Goyer, L F Major

Aggression in humans correlates with cerebrospinal fluid amine metabolites

G L Brown et al. Psychiatry Res. 1979 Oct.

Abstract

Cerebrospinal fluid of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)--5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life. Independently scored history of aggressive behavior showed a significant negative correlation with 5HIAA (r = -0.78) and a significant positive correlation with MHPG (r = 0.64).

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