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. 1998 Feb;82(1):1-4.
doi: 10.1016/S0165-5728(97)00170-7.

Interferon beta normalizes suppressor cell function in dysimmune neuropathies

Giovanna De Luca  1 , Alessandra Lugaresi  1 , Carla Iarlori  1 , Fabio Marzoli  1 , Antonino Uncini  1 , Domenico Gambi  1
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Interferon beta normalizes suppressor cell function in dysimmune neuropathies

Giovanna De Luca et al. J Neuroimmunol. 1998 Feb.

Abstract

We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon beta, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon beta might represent an adjunctive therapy in CIDP both acting on a defective blood-nerve barrier and normalizing an otherwise defective suppressor cell function.

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