Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jan-Feb;53(1-2):135-8.
doi: 10.1515/znc-1998-1-223.

Interaction of histone H1 with cis-platinum modified DNA

E G Paneva  1 , N C Spassovska, K C Grancharov, J S Zlatanova, J N Yaneva
Affiliations
Free article

Interaction of histone H1 with cis-platinum modified DNA

E G Paneva et al. Z Naturforsch C J Biosci. 1998 Jan-Feb.
Free article

Abstract

Cis-diamminedichloroplatinum(II) (cis-DDP) is known as an effective anticancer drug. Its therapeutic effect is supposed to be a consequence of the covalent binding to DNA. A number of cellular proteins were found to bind selectively to DNA modified by cis-DDP (but not by its isomer trans-DDP). Here we present our observations on interaction of the linker histone H1 with cis- and trans-DDP modified DNA fragments. The results afford new experimental information about the preferential binding of histone H1 to cis-DDP-distorted DNAs versus trans-DDP modified ones.

PubMed Disclaimer

Publication types

LinkOut - more resources