Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Mar 24;97(11):1042-5.
doi: 10.1161/01.cir.97.11.1042.

Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B

R A Kloner  1 , T Shook, E M Antman, C P Cannon, K Przyklenk, K Yoo, C H McCabe, E Braunwald
Affiliations

Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B

R A Kloner et al. Circulation. .

Abstract

Background: The timing of onset of angina before myocardial infarction in relation to outcome is unknown.

Methods and results: We prospectively determined the importance of the time of onset of preinfarction angina in relation to 30-day outcomes in the TIMI-9B study from standardized forms. Of the 3002 patients entered into the study, 425 reported angina before their myocardial infarction. Patients with angina onset within 24 hours of infarction had a lower 30-day cardiac event rate (mortality, recurrent myocardial infarction, heart failure, or shock) at 4% than those with onset of angina >24 hours (17%; P=.030). A history of any angina alone was not associated with reduced event rate. Peak creatine kinase levels tended to be lower in the group with angina within 24 hours. These benefits were not due to higher rates of use of antianginal medicines or aspirin and were not a consequence of differences in baseline characteristics or disease states (hypertension, hypercholesterolemia) among subgroups.

Conclusions: These temporal observations are consistent with the concept of preconditioning by preinfarction angina but do not rule out other mechanisms.

PubMed Disclaimer