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. 1998 Jan;78(1):F20-4.
doi: 10.1136/fn.78.1.f20.

Pulmonary artery pressure: early predictor of chronic lung disease in preterm infants

N V Subhedar  1 , A H Hamdan, S W Ryan, N J Shaw
Affiliations

Pulmonary artery pressure: early predictor of chronic lung disease in preterm infants

N V Subhedar et al. Arch Dis Child Fetal Neonatal Ed. 1998 Jan.

Abstract

Aim: To determine if pulmonary artery pressure (PAP) in ventilated preterm infants is independently associated with the development of chronic lung disease (CLD) and whether early assessment has any prognostic value.

Methods: Two cohorts (development n = 55; and validation n = 28) of preterm infants were studied at 24 hours of age. PAP was assessed non-invasively using its inverse correlation with the corrected acceleration time to right ventricular ejection time ratio (AT:RVET(c)), calculated from the pulmonary artery Doppler waveform. Clinical and respiratory variables were also collected. Using logistic regression analysis to identify factors independently associated with CLD, a prognostic score was developed to predict CLD. The ability of the score to predict CLD was described using receiver operating characteristic (ROC) curves.

Results: Birthweight, inspired oxygen concentration, and AT:RVET(c) were independently predictive of CLD. The area under the ROC curve was 0.96 for the development and 0.89 for the validation cohort. Exclusion of AT:RVET(c) resulted in a reduction to 0.88 and 0.73, respectively.

Conclusion: PAP is independently associated with CLD. An early assessment of PAP using AT:RVET(c) may permit the early prediction of CLD as part of a multifactorial scoring system.

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