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Clinical Trial
. 1998 Jan;78(1):F43-5.
doi: 10.1136/fn.78.1.f43.

Central-peripheral temperature difference, blood pressure, and arginine vasopressin in preterm neonates undergoing volume expansion

H J Lambert  1 , P H Baylis, M G Coulthard
Affiliations
Clinical Trial

Central-peripheral temperature difference, blood pressure, and arginine vasopressin in preterm neonates undergoing volume expansion

H J Lambert et al. Arch Dis Child Fetal Neonatal Ed. 1998 Jan.

Abstract

Aim: To examine the effect of intravascular volume expansion for the treatment of hypovolaemia in sick preterm neonates.

Methods: An intravenous infusion of 20 ml per kg of 4.5% albumin was given to 14 preterm neonates. The effects on systolic blood pressure, central peripheral temperature difference (c-pT), and plasma arginine vasopressin concentration (pAVP) were measured.

Results: Thirteen babies showed a rise in systolic blood pressure. The six babies with the highest initial values of pAVP and c-pT showed a fall in both of these after infusion. The babies with lower initial pAVP (below 4 pmol/l) showed either a rise (two) or no change (six) after albumin infusion. There was a significant correlation between c-pT and log pAVP before (r2 = 0.61; p < 0.05) and after infusion (r2 = 0.45; p < 0.05).

Conclusions: Plasma AVP concentration is related to c-pT in unwell preterm newborns. This study suggests that clinical assessment of hypovolaemia in preterm newborns is poor and could be improved by using c-pT.

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