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Review
. 1998 Apr 14;95(8):4077-80.
doi: 10.1073/pnas.95.8.4077.

The "best" of cholesterols, the "worst" of cholesterols: a tale of two receptors

M Krieger  1
Affiliations
Review

The "best" of cholesterols, the "worst" of cholesterols: a tale of two receptors

M Krieger. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
LDL and the LDL receptor in cholesterol transport. The liver secretes the triglyceride-rich VLDL, which is converted to IDL and then to cholesterol-rich LDL. Plasma LDL cholesterol levels are controlled by the receptor-mediated endocytic clearance of LDL from the circulation by LDL receptors. These receptors are expressed most abundantly in the liver but also are found in many other tissues (see text for details).
Figure 2
Figure 2
HDL and the HDL receptor SR-BI in cholesterol transport. HDL is thought to remove unesterified, or “free” cholesterol (FC) from peripheral tissues, after which most of the cholesterol is converted to cholesteryl ester (CE) by enzymes in the plasma. Subsequently, HDL cholesterol is efficiently delivered directly to the liver and steroidogenic tissues via a selective uptake pathway and SR-BI or, in some species, transferred to other lipoproteins for additional transport and metabolism.
See this image and copyright information in PMC

Comment on

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