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. 1998 Jan;72(5):279-83.
doi: 10.1016/s0031-6865(97)00025-3.

Amide derivatives with H1-antihistaminic effect

C Saturnino  1 , P Saturnino, G De Martino, J C Lancelot, D Perrine, R Boureau, M Robba
Affiliations

Amide derivatives with H1-antihistaminic effect

C Saturnino et al. Pharm Acta Helv. 1998 Jan.

Abstract

The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.

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