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. 1998 Mar 9;1396(2):127-31.
doi: 10.1016/s0167-4781(97)00192-9.

Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis

T Seki  1 , M Seki, T Katada, T Enomoto
Affiliations

Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis

T Seki et al. Biochim Biophys Acta. .

Abstract

A cDNA (mTOP3) encoding mouse DNA topoisomerase III (topo III) was cloned using the human TOP3 cDNA as a probe. The deduced amino acid sequence of mouse topo III showed 86.8% identity with that of human topo III. Mouse TOP3 mRNA was highly expressed in the testis in comparison with other tissues. The TOP3 mRNA level in the testis increased slightly 14 days after birth and showed a marked increase in 17 days, times when the cells in pachytene phase begin to appear and increase in number.

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