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. 1998 Apr;91(4):615-7.
doi: 10.1016/s0029-7844(97)00709-6.

Hyperemesis gravidarum associated with Helicobacter pylori seropositivity

P Frigo  1 , C Lang, K Reisenberger, H Kölbl, A M Hirschl
Affiliations

Hyperemesis gravidarum associated with Helicobacter pylori seropositivity

P Frigo et al. Obstet Gynecol. 1998 Apr.

Abstract

Objective: To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.

Methods: From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation.

Results: Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A chi2 test showed statistical significance (P < .001). The mean (+/-standard deviation) index percentages of the IgG titers were 74.2+/-23.6% in the hyperemesis group and 24.3+/-4.4% in the control group (P < .01, Student t test).

Conclusion: Infection with H pylori may cause hyperemesis gravidarum.

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