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. 1998 Jan;53(1):33-40.
doi: 10.1016/s0014-827x(97)00002-5.

Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents

A M Almerico  1 , P Diana, P Barraja, G Dattolo, F Mingoia, A G Loi, F Scintu, C Milia, I Puddu, P La Colla
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Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents

A M Almerico et al. Farmaco. 1998 Jan.

Abstract

Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found.

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