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Clinical Trial
. 1998 Mar;132(3 Pt 1):543-6.
doi: 10.1016/s0022-3476(98)70039-3.

A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

M W Kline  1 , C V Fletcher, A T Harris, K D Evans, R C Brundage, R P Remmel, N R Calles, S B Kirkpatrick, C Simon
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Clinical Trial

A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

M W Kline et al. J Pediatr. 1998 Mar.

Abstract

Twelve children infected with the human immunodeficiency virus were treated orally with indinavir, stavudine, plus didanosine for 12 to 48 weeks. Therapy was limited in some cases by nonadherence, intolerance, toxicity, and virologic failure. Marked increases in CD4+ lymphocyte counts and decreases in plasma human immunodeficiency virus RNA concentrations suggest that the regimen has potent antiviral activity.

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