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Comparative Study
. 1998 Feb;51(2):145-52.
doi: 10.7164/antibiotics.51.145.

New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

K A Dekker  1 , T Inagaki, T D Gootz, L H Huang, Y Kojima, W E Kohlbrenner, Y Matsunaga, P R McGuirk, E Nomura, T Sakakibara, S Sakemi, Y Suzuki, Y Yamauchi, N Kojima
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Free article
Comparative Study

New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

K A Dekker et al. J Antibiot (Tokyo). 1998 Feb.
Free article

Abstract

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.

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