doi: 10.1007/BF00292945.
Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome
- PMID: 954549
- DOI: 10.1007/BF00292945
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Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome
Chromosoma.
.
Abstract
The distribution of mitotic chiasmata from the lymphocytes of three patients with Bloom's syndrome was studied by Q-banding. An estimate was made of the average brightness of the human chromosomes and of the brightness and length of the Q-regions. A strong relationship was found between the average darkness of a chromosome and its chiasma density. The shorter and darker Q-regions contained more chiasmata, with the exception of the chromosome tips which had lower chiasma densities. A few "hot spots" had particularly high chiasma densities. Centric regions contained 17% of the chiasmata. The data are consistent with the assumptions that chiasmata are favored in darker regions and at borders between light and dark regions.
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