doi: 10.1210/endo-99-3-780.
The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas
- PMID: 954669
- DOI: 10.1210/endo-99-3-780
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The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas
Endocrinology.
1976 Sep.
Abstract
Gastric inhibitory polypeptide (GIP) produced a dose-related increase in immunoreactive insulin (IRI) from the perfused isolated rat pancreas. The doses employed were within physiological limits. This effect was glucose-concentration-dependent in that there existed a threshold concentration of glucose above which GIP exerted the insulinotropic action, and that, at a fixed concentration of GIP, increased glucose concentrations stimulated IRI release in more than an additive manner. A biologically active fragment of the GIP molecule was isolated and purified. All criteria have been satisfied that GIP is an insulinotropic hormone.
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