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. 1998 Mar;46(3):423-9.
doi: 10.1248/cpb.46.423.

Immunosuppressive components from an Ascomycete, Diplogelasinospora grovesii

H Fujimoto  1 , J Nagano, K Yamaguchi, M Yamazaki
Affiliations

Immunosuppressive components from an Ascomycete, Diplogelasinospora grovesii

H Fujimoto et al. Chem Pharm Bull (Tokyo). 1998 Mar.

Abstract

Two known fungal metabolites, macrophin and colletodiol, and a new stereoisomer of colletodiol named 10-epi-colletodiol, were isolated as immunosuppressive principles from an Ascomycete, Diplogelasinospora grovesii. The IC50 values of the major active component among them, macrophin, were calculated to be 0.4 and 0.3 microgram/ml against concanavalin A- and lipopolysaccharide-induced proliferations of mouse spleen lymphocytes, respectively. A new natural product, 4,8-dimethyl-1,5-dioxacyclooctane-2,6-dione, and a known fungal metabolite, isosclerone, which showed no immunosuppressive activity, were also isolated from this fungus.

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