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. 1976 Aug 15;32(8):1015-7.
doi: 10.1007/BF01933945.

Deficiency in renomedullary prostaglandin synthesis related to the evolution of essential hypertension

N Papanicolaou, T Mountokalakis, M Safar, J Bariety, P Milliez

Deficiency in renomedullary prostaglandin synthesis related to the evolution of essential hypertension

N Papanicolaou et al. Experientia. .

Abstract

Continued PG synthesis in the early stages of essential hypertension might reflect an activation of the renal antihypertensive function in respect to neurogenic and/or hormonal pression stimuli, subsequently a deficiency of renal PG synthesis related to irreversible changes with the kidney would lead to the prepoderance of a pressure mechanism, resulting to a further increase of blood pressure.

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