Preparation and characterization of live recombinant influenza vaccine
- PMID: 955267
Item in Clipboard
Preparation and characterization of live recombinant influenza vaccine
Dev Biol Stand.
1976.
Abstract
Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.
Similar articles
-
A clinical trial of WRL 105 strain live attenuated influenza vaccine comparing four methods of intranasal vaccination.Dev Biol Stand. 1976;33:202-6. Dev Biol Stand. 1976. PMID: 782970 Clinical Trial.
-
Natural challenge of subjects vaccinated with WRL 105 strain live influenza vaccine in a residential community.Dev Biol Stand. 1976;33:197-201. Dev Biol Stand. 1976. PMID: 782969 Clinical Trial.
-
Clinical trials with intranasally administered WRL 105 strain live influenza vaccine in volunteers.Dev Biol Stand. 1976;33:207-12. Dev Biol Stand. 1976. PMID: 782971 Clinical Trial.
-
Response of ferrets to infection with a live attenuated influenza virus and to subsequent heterologous challenge.Dev Biol Stand. 1976;33:226-33. Dev Biol Stand. 1976. PMID: 955269
-
[Genetic approaches to the development and study of vaccine strains of RNA viruses].Zh Mikrobiol Epidemiol Immunobiol. 1973 Dec;50(12):67-73. Zh Mikrobiol Epidemiol Immunobiol. 1973. PMID: 4594662 Review. Russian. No abstract available.
Cited by
-
Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers.J Hyg (Lond). 1979 Jun;82(3):489-95. doi: 10.1017/s0022172400054012. J Hyg (Lond). 1979. PMID: 448065 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical