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Review
. 1998 Apr 24;280(5363):547-53.
doi: 10.1126/science.280.5363.547.

Structure and function in the nucleus

A I Lamond  1 , W C Earnshaw
Affiliations
Free article
Review

Structure and function in the nucleus

A I Lamond et al. Science. .
Free article

Abstract

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

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